| 1 | Brazilian Grand Prix | 1988-04-03 | Autódromo Internacional Nelson Piquet
Rio de Janeiro, Brazil | Alain Prost (McLaren) |
| 2 | San Marino Grand Prix | 1988-05-01 | Autodromo Enzo e Dino Ferrari
Imola, Italy | Ayrton Senna (McLaren) |
| 3 | Monaco Grand Prix | 1988-05-15 | Circuit de Monaco
Monte-Carlo, Monaco | Alain Prost (McLaren) |
| 4 | Mexican Grand Prix | 1988-05-29 | Autódromo Hermanos Rodríguez
Mexico City, Mexico | Alain Prost (McLaren) |
| 5 | Canadian Grand Prix | 1988-06-12 | Circuit Gilles Villeneuve
Montreal, Canada | Ayrton Senna (McLaren) |
| 6 | Detroit Grand Prix | 1988-06-19 | Detroit Street Circuit
Detroit, USA | Ayrton Senna (McLaren) |
| 7 | French Grand Prix | 1988-07-03 | Circuit Paul Ricard
Le Castellet, France | Alain Prost (McLaren) |
| 8 | British Grand Prix | 1988-07-10 | Silverstone Circuit
Silverstone, UK | Ayrton Senna (McLaren) |
| 9 | German Grand Prix | 1988-07-24 | Hockenheimring
Hockenheim, Germany | Ayrton Senna (McLaren) |
| 10 | Hungarian Grand Prix | 1988-08-07 | Hungaroring
Budapest, Hungary | Ayrton Senna (McLaren) |
| 11 | Belgian Grand Prix | 1988-08-28 | Circuit de Spa-Francorchamps
Spa, Belgium | Ayrton Senna (McLaren) |
| 12 | Italian Grand Prix | 1988-09-11 | Autodromo Nazionale di Monza
Monza, Italy | Gerhard Berger (Ferrari) |
| 13 | Portuguese Grand Prix | 1988-09-25 | Autódromo do Estoril
Estoril, Portugal | Alain Prost (McLaren) |
| 14 | Spanish Grand Prix | 1988-10-02 | Circuito de Jerez
Jerez de la Frontera, Spain | Alain Prost (McLaren) |
| 15 | Japanese Grand Prix | 1988-10-30 | Suzuka Circuit
Suzuka, Japan | Ayrton Senna (McLaren) |
| 16 | Australian Grand Prix | 1988-11-13 | Adelaide Street Circuit
Adelaide, Australia | Alain Prost (McLaren) |