| 1 | United States Grand Prix West | 1981-03-15 | Long Beach
California, USA | Alan Jones (Williams) |
| 2 | Brazilian Grand Prix | 1981-03-29 | Autódromo Internacional Nelson Piquet
Rio de Janeiro, Brazil | Carlos Reutemann (Williams) |
| 3 | Argentine Grand Prix | 1981-04-12 | Autódromo Juan y Oscar Gálvez
Buenos Aires, Argentina | Nelson Piquet (Brabham) |
| 4 | San Marino Grand Prix | 1981-05-03 | Autodromo Enzo e Dino Ferrari
Imola, Italy | Nelson Piquet (Brabham) |
| 5 | Belgian Grand Prix | 1981-05-17 | Zolder
Heusden-Zolder, Belgium | Carlos Reutemann (Williams) |
| 6 | Monaco Grand Prix | 1981-05-31 | Circuit de Monaco
Monte-Carlo, Monaco | Gilles Villeneuve (Ferrari) |
| 7 | Spanish Grand Prix | 1981-06-21 | Jarama
Madrid, Spain | Gilles Villeneuve (Ferrari) |
| 8 | French Grand Prix | 1981-07-05 | Dijon-Prenois
Dijon, France | Alain Prost (Renault) |
| 9 | British Grand Prix | 1981-07-18 | Silverstone Circuit
Silverstone, UK | John Watson (McLaren) |
| 10 | German Grand Prix | 1981-08-02 | Hockenheimring
Hockenheim, Germany | Nelson Piquet (Brabham) |
| 11 | Austrian Grand Prix | 1981-08-16 | Red Bull Ring
Spielberg, Austria | Jacques Laffite (Ligier) |
| 12 | Dutch Grand Prix | 1981-08-30 | Circuit Park Zandvoort
Zandvoort, Netherlands | Alain Prost (Renault) |
| 13 | Italian Grand Prix | 1981-09-13 | Autodromo Nazionale di Monza
Monza, Italy | Alain Prost (Renault) |
| 14 | Canadian Grand Prix | 1981-09-27 | Circuit Gilles Villeneuve
Montreal, Canada | Jacques Laffite (Ligier) |
| 15 | Caesars Palace Grand Prix | 1981-10-17 | Las Vegas Street Circuit
Nevada, USA | Alan Jones (Williams) |